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Multifunctional chitosan-copper-gallic acid based antibacterial nanocomposite wound dressing.
- Source :
-
International journal of biological macromolecules [Int J Biol Macromol] 2021 Jan 15; Vol. 167, pp. 10-22. Date of Electronic Publication: 2020 Nov 27. - Publication Year :
- 2021
-
Abstract
- Antibacterial wound dressings can effectively avoid the residual of antibacterial nanomaterials for injection in vivo, reduce their biological toxicity to normal cells and tissues, making them be widely applied in biomedical field. Herein, an approach of combining ion-crosslinking, in-situ reduction and microwave-assisted methods was employed to prepare chitosan-copper-gallic acid nanocomposites (CS-Cu-GA NCs) with dual-functional nano-enzyme characteristics (oxidase- and peroxidase-like functions). The oxidase-like activity of CS-Cu-GA NCs can facilitate the production of hydrogen peroxide (H <subscript>2</subscript> O <subscript>2</subscript> ) when it contacted with physiologically relevant antioxidants (AH <subscript>2</subscript> ) in bacteria. Subsequently, H <subscript>2</subscript> O <subscript>2</subscript> was catalyzed to generate hydroxyl radicals (OH) under the peroxidase-like activity of CS-Cu-GA NCs. Furthermore, CS-Cu-GA NCs integrate the inherent antibacterial properties of chitosan, Cu NPs and Cu <superscript>2+</superscript> . Animal experiments revealed that the antibacterial dressing incorporating CS-Cu-GA NCs exhibited its effective promotion of S. aureus-infected wounds healing, as well as no damage to normal tissues. Besides, the antibacterial dressing was prepared to a band aid with excellent water swelling and antibacterial properties, which was further fixed in a medical tape to construct a portable antibacterial product that can be applied to the surface of human skin and showed excellent waterproof performance, providing a new insight for the construction of clinical antibacterial wound healing products.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Catalysis
Humans
Mice
Microbial Sensitivity Tests
Nanocomposites ultrastructure
Spectroscopy, Fourier Transform Infrared
X-Ray Diffraction
Anti-Bacterial Agents chemistry
Anti-Bacterial Agents pharmacology
Bandages
Chitosan chemistry
Copper chemistry
Gallic Acid chemistry
Nanocomposites chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0003
- Volume :
- 167
- Database :
- MEDLINE
- Journal :
- International journal of biological macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 33249153
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2020.11.153