Back to Search Start Over

Nanospheres loaded with curcumin promote gut epithelial motility through F-actin-related migration signaling events.

Authors :
Kim JY
Min T
Lee SJ
Source :
The Journal of nutritional biochemistry [J Nutr Biochem] 2021 Feb; Vol. 88, pp. 108555. Date of Electronic Publication: 2020 Nov 26.
Publication Year :
2021

Abstract

Curcumin, a hydrophobic polyphenol of turmeric, has a variety of biological functions as an herbal supplement, but its poor gastric absorption rate is one of the major factors limiting its oral bioavailability. In the present study, we investigated the functional role of nanospheres loaded with curcumin (nCur) with regard to the motility of gut epithelial HCT116 cells and enterocyte migration along the crypt-villus axis. nCur significantly increased the motility of HCT116 cells and showed much higher migration efficacy than the curcumin. nCur stimulated the small GTPases Rac1 and the phosphorylation of protein kinase C, responsible for the distinctive activation of the mitogen-activated protein kinases. Interestingly, nCur significantly induced the expression of α-actinin, profilin-1, and filamentous (F)-actin as regulated by the phosphorylation of nuclear factor-kappa B during its promotion of cell migration. In mouse models of gut epithelial migration, treatment with nCur had an enhancing effect on the movement of enterocytes along the crypt-villus axis and the expression of cytoskeletal reorganization-related factors. These results indicate that nCur is a functional agent that promotes gut epithelial motility through F-actin-related migration signaling events.<br />Competing Interests: Conflicts of Interest The authors have declared that there is no conflict of interest.<br /> (Copyright © 2020. Published by Elsevier Inc.)

Details

Language :
English
ISSN :
1873-4847
Volume :
88
Database :
MEDLINE
Journal :
The Journal of nutritional biochemistry
Publication Type :
Academic Journal
Accession number :
33249186
Full Text :
https://doi.org/10.1016/j.jnutbio.2020.108555