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Presumptive Lornoxicam Intoxication in Four Dogs.
- Source :
-
Topics in companion animal medicine [Top Companion Anim Med] 2021 Mar; Vol. 42, pp. 100502. Date of Electronic Publication: 2020 Nov 26. - Publication Year :
- 2021
-
Abstract
- Lornoxicam is a nonsteroidal anti-inflammatory drug extensively used in human medicine, which is not approved for canine use. Lornoxicam intoxication has been rarely reported in dogs. Four dogs of various breeds, aged 7 months to 10 years, were admitted with a recent history of melena, anorexia and depression, occurring 1-4 days after the ingestion of lornoxicam (dose range: 0.53-2.7 [median 1.17] mg/kg). No clinically relevant comorbidities were documented, but low doses of prednisolone had been given in 3 of the dogs, in close temporal association with lornoxicam. Major clinical and clinicopathologic findings on admission included mucosal pallor, melena, depression, severe anemia, neutrophilic leucocytosis, and panhypoproteinemia. Perforated pyloric and duodenal ulcers were documented in 3 dogs by exploratory celiotomy or postmortem. Prolonged hospitalization (5-20 days) with extensive supportive care and multiple blood transfusions was required in 3 of the 4 dogs who survived to discharge. Lornoxicam ingestion may cause protracted and severe gastrointestinal tract injury and bleeding, blood loss anemia, panhypoproteinemia, and perforated gastrointestinal ulcers, associated with significant morbidity and mortality in dogs.<br />Competing Interests: Declaration of Competing Interest The authors have no conflicts of interest to declare.<br /> (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Subjects :
- Anemia chemically induced
Animals
Anti-Inflammatory Agents, Non-Steroidal administration & dosage
Dogs
Gastrointestinal Diseases veterinary
Gastrointestinal Hemorrhage chemically induced
Gastrointestinal Hemorrhage complications
Piroxicam administration & dosage
Piroxicam adverse effects
Piroxicam pharmacology
Anemia veterinary
Anti-Inflammatory Agents, Non-Steroidal adverse effects
Digestive System drug effects
Dog Diseases
Gastrointestinal Hemorrhage veterinary
Piroxicam analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1946-9837
- Volume :
- 42
- Database :
- MEDLINE
- Journal :
- Topics in companion animal medicine
- Publication Type :
- Report
- Accession number :
- 33249243
- Full Text :
- https://doi.org/10.1016/j.tcam.2020.100502