Back to Search
Start Over
Saffron: Chemical Composition and Neuroprotective Activity.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2020 Nov 29; Vol. 25 (23). Date of Electronic Publication: 2020 Nov 29. - Publication Year :
- 2020
-
Abstract
- Crocus sativus L. belongs to the Iridaceae family and it is commonly known as saffron. The different cultures together with the geoclimatic characteristics of the territory determine a different chemical composition that characterizes the final product. This is why a complete knowledge of this product is fundamental, from which more than 150 chemical compounds have been extracted from, but only about one third of them have been identified. The chemical composition of saffron has been studied in relation to its efficacy in coping with neurodegenerative retinal diseases. Accordingly, experimental results provide evidence of a strict correlation between chemical composition and neuroprotective capacity. We found that saffron's ability to cope with retinal neurodegeneration is related to: (1) the presence of specific crocins and (2) the contribution of other saffron components. We summarize previous evidence and provide original data showing that results obtained both "in vivo" and "in vitro" lead to the same conclusion.
- Subjects :
- Adenosine Triphosphate analogs & derivatives
Adenosine Triphosphate pharmacology
Animals
Calcium metabolism
Carotenoids chemistry
Carotenoids metabolism
Carotenoids pharmacology
Cell Line, Tumor
Cell Survival
Chromatography, High Pressure Liquid
Crocus metabolism
Disease Models, Animal
Flowers chemistry
HEK293 Cells
Humans
Light adverse effects
Mice
Neurodegenerative Diseases drug therapy
Neuroprotective Agents isolation & purification
Plant Extracts isolation & purification
Rats, Sprague-Dawley
Receptors, Purinergic P2X7 drug effects
Retina diagnostic imaging
Retina drug effects
Retinal Degeneration drug therapy
Retinal Degeneration etiology
Vitamin A analogs & derivatives
Vitamin A metabolism
Crocus chemistry
Neuroprotective Agents chemistry
Neuroprotective Agents pharmacology
Plant Extracts chemistry
Plant Extracts pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 25
- Issue :
- 23
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 33260389
- Full Text :
- https://doi.org/10.3390/molecules25235618