BCR-ABL1 compound mutants: prevalence, spectrum and correlation with tyrosine kinase inhibitor resistance in a consecutive series of Philadelphia chromosome-positive leukemia patients analyzed by NGS.

Subjects

Subjects :

High-Throughput Nucleotide Sequencing methods
Humans
Prevalence
Drug Resistance, Neoplasm genetics
Fusion Proteins, bcr-abl genetics
Leukemia drug therapy
Leukemia genetics
Philadelphia Chromosome drug effects
Protein Kinase Inhibitors pharmacology
Protein-Tyrosine Kinases antagonists & inhibitors

Details

Language :

English

ISSN :

1476-5551

Volume :

35

Issue :

7

Database :

MEDLINE

Journal :

Leukemia

Publication Type :

Academic Journal

Accession number :

33262525

Full Text :

https://doi.org/10.1038/s41375-020-01098-w