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Contribution of long noncoding RNA HOTAIR variants to preeclampsia susceptibility in Iranian women.
- Source :
-
Hypertension in pregnancy [Hypertens Pregnancy] 2021 Feb; Vol. 40 (1), pp. 29-35. Date of Electronic Publication: 2020 Dec 02. - Publication Year :
- 2021
-
Abstract
- Objective : To investigate the possible association of lncRNA HOTAIR rs920778 and rs874945 polymorphisms with preeclampsia risk in a sample from the Iranian population. Method : The study subjects included 250 preeclamptic women and 250 healthy women. The genotyping for rs920778 and rs874945 polymorphisms were performed using the TP-ARMS-PCR method. Results : HOTAIR rs920778 increased the risk of preeclampsia under the dominant and recessive inheritance patterns (OR = 4.84, 95% CI: 3.30-7.10, P < 0.0001; OR = 6.86, 95% CI: 3.51-13.42, P < 0.0001; respectively). Conclusion : This study confirmed the association of HOTAIR rs920778 polymorphism with preeclampsia in Iranian women. Further studies should be performed to confirm our findings.
Details
- Language :
- English
- ISSN :
- 1525-6065
- Volume :
- 40
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Hypertension in pregnancy
- Publication Type :
- Academic Journal
- Accession number :
- 33264034
- Full Text :
- https://doi.org/10.1080/10641955.2020.1855192