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Ganglioglioma of optic chiasma: A case report and review of literature.

Authors :: Abuzayed B
Alawneh K
Al-Qawasmeh M
Al-Khatib S
Barukba M
Raffee L
Source :: Surgical neurology international [Surg Neurol Int] 2020 Nov 18; Vol. 11, pp. 392. Date of Electronic Publication: 2020 Nov 18 (Print Publication: 2020).
Publication Year :: 2020
Abstract: Background: Gangliogliomas are neoplasms containing both astrocytic and neuronal components. We present a case of gangliogliomas of the optic chiasm, which are extremely rare pathologies.<br />Case Description: A 16-year-old female patient referred to our clinic with gradual deterioration of vision for the age of 1 year mostly in the right eye. Ophthalmic examination confirmed reduced visual acuity with only perception of light in the left eye. Brain magnetic resonance imaging showed a solid mass lesion involving the hypothalamus and the optic chiasm, which was hypointense on T1-weighted images, hyperintense on T2-WI, and marked homogenous contrast enhancement. The patient was operated and bulging of the optic chiasm and the site of lamina terminalis was seen. Subtotal resection of the tumor was achieved. Histopathological examination revealed ganglioglioma (WHO Grade I). Follow-up of the patient was for 3 years and 8 months with stable neurologic and radiologic findings.<br />Conclusion: To the best of our knowledge, 20 cases, including ours, have been reported in the literature and a presurgical diagnosis of ganglioglioma is very infrequent with confused radiologically with low-grade pilocytic astrocytomas.<br />Competing Interests: There are no conflicts of interest.<br /> (Copyright: © 2020 Surgical Neurology International.)