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[COVID-19-associated multisystem inflammatory syndrome in children: case series at a pediatric hospital in Peru].
- Source :
-
Revista peruana de medicina experimental y salud publica [Rev Peru Med Exp Salud Publica] 2020 Dec 02; Vol. 37 (3), pp. 559-565. - Publication Year :
- 2020
-
Abstract
- During the COVID-19 pandemic, a new, severe and unusual condition called Multisystem Inflammatory Syndrome in children emerged, from which there is still much to learn. We report 8 children admitted to Instituto Nacional de Salud del Niño, in Lima, Perú. Their mean age was 5,1 years. Their clinical presentation included fever, acute gastrointestinal symptoms, ocular and mucocutaneous involvement. Four patients met criteria for classic Kawasaki Disease. All the patients had positive serology for SARS-CoV-2, abnormal complete blood counts and coagulation tests, and elevated inflammatory markers. Five had elevated liver enzymes and three had kidney involvement. Four patients met criteria for Macrophage Activation Syndrome. All of them received intravenous immune globulin, corticosteroids and aspirin. No coronary aneurysms were identified. Only one developed miocarditis, shock and was admitted to the Pediatric Intensive Care Unit. Most patients recovered successfully. Every child with fever, gastrointestinal and dermatological symptoms, associated with prior exposure to SARS-CoV-2, should be investigated for multi-systemic compromise.
- Subjects :
- Adrenal Cortex Hormones administration & dosage
Antibodies, Viral analysis
COVID-19 blood
Child
Child, Preschool
Female
Hospitals, Pediatric
Humans
Immunoglobulin G analysis
Immunoglobulin M analysis
Immunoglobulins, Intravenous administration & dosage
Immunologic Factors administration & dosage
Infant
Macrophage Activation Syndrome diagnosis
Male
Peru
Systemic Inflammatory Response Syndrome blood
Systemic Inflammatory Response Syndrome drug therapy
Treatment Outcome
COVID-19 Drug Treatment
COVID-19 diagnosis
Mucocutaneous Lymph Node Syndrome diagnosis
SARS-CoV-2 immunology
Systemic Inflammatory Response Syndrome diagnosis
Subjects
Details
- Language :
- Spanish; Castilian
- ISSN :
- 1726-4642
- Volume :
- 37
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Revista peruana de medicina experimental y salud publica
- Publication Type :
- Report
- Accession number :
- 33295562
- Full Text :
- https://doi.org/10.17843/rpmesp.2020.373.6126