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Ferula L. Plant Extracts and Dose-Dependent Activity of Natural Sesquiterpene Ferutinin: From Antioxidant Potential to Cytotoxic Effects.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2020 Dec 07; Vol. 25 (23). Date of Electronic Publication: 2020 Dec 07. - Publication Year :
- 2020
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Abstract
- The employment studies of natural extracts in the prevention and treatment of several diseases highlighted the role of different species of genus Ferula L., belonging to the Apiaceae family, dicotyledonous plants present in many temperate zones of our planet. Ferula communis L. is the main source of sesquiterpene ferutinin, a bioactive compound studied both in vitro and in vivo, because of different effects, such as phytoestrogenic, antioxidant, anti-inflammatory, but also antiproliferative and cytotoxic activity, performed in a dose-dependent and cell-dependent way. The present review will focus on the molecular mechanisms involved in the different activities of Ferutinin, starting from its antioxidant potential at low doses until its ionophoric property and the subsequent mitochondrial dysfunction induced through administration of high doses, which represent the key point of its anticancer action. Furthermore, we will summarize the data acquired from some experimental studies on different cell types and on several diseases. The results obtained showed an important antioxidant and phytoestrogenic regulation with lack of typical side effects related to estrogenic therapy. The preferential cell death induction for tumor cell lines suggests that ferutinin may have anti-neoplastic properties, and may be used as an antiproliferative and cytotoxic agent in an estrogen dependent and independent manner. Nevertheless, more data are needed to clearly understand the effect of ferutinin in animals before using it as a phytoestrogen or anticancer drug.
- Subjects :
- Antineoplastic Agents chemistry
Antineoplastic Agents therapeutic use
Antioxidants chemistry
Antioxidants therapeutic use
Apoptosis drug effects
Benzoates chemistry
Benzoates therapeutic use
Bridged Bicyclo Compounds chemistry
Bridged Bicyclo Compounds pharmacology
Bridged Bicyclo Compounds therapeutic use
Cell Line, Tumor
Cycloheptanes chemistry
Cycloheptanes therapeutic use
Dose-Response Relationship, Drug
Electron Transport drug effects
Hormone Replacement Therapy
Humans
Mitochondria drug effects
Mitochondria metabolism
Nitric Oxide metabolism
Phytochemicals chemistry
Phytochemicals pharmacology
Phytoestrogens chemistry
Phytoestrogens pharmacology
Plant Extracts chemistry
Plant Extracts therapeutic use
Reactive Oxygen Species metabolism
Sesquiterpenes chemistry
Sesquiterpenes therapeutic use
Antineoplastic Agents pharmacology
Antioxidants pharmacology
Benzoates pharmacology
Cycloheptanes pharmacology
Ferula chemistry
Plant Extracts pharmacology
Sesquiterpenes pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 25
- Issue :
- 23
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 33297504
- Full Text :
- https://doi.org/10.3390/molecules25235768