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NIR-II pH Sensor with a FRET Adjustable Transition Point for In Situ Dynamic Tumor Microenvironment Visualization.
- Source :
-
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2021 Mar 01; Vol. 60 (10), pp. 5091-5095. Date of Electronic Publication: 2021 Jan 26. - Publication Year :
- 2021
-
Abstract
- Monitoring the pH in tumor lesions provides abundant physiological information. However, currently developed pH sensors only achieve sensitive detection in the settled response region around the pH transition point (pH <subscript>t</subscript> ). To realize tumor pH monitoring with high sensitivity within a wider response region, reported here are serial pH <subscript>t</subscript> adjustable sensors (pTAS) that simply regulate the component ratio of second near-infrared (NIR-II) emission aza-BODIPY (NAB) donor and pH sensitive rhodamine-based pre-acceptor (NRh) in Förster resonance energy transfer system. Combining the pH response regions of pTAS, a twofold widened pH detection range (6.11-7.22) is obtained compared to the pH <subscript>t</subscript> settled sensor (6.38-6.94). With an adjustable pH <subscript>t</subscript> , in vivo tumor pH increase and decrease processes could be dynamically visualized through dual-channel ratiometric bioimaging within the NIR-II window, with a coefficient of variation under 1 % compared to the standard pH meter.<br /> (© 2021 Wiley-VCH GmbH.)
- Subjects :
- Animals
Boron Compounds chemical synthesis
Boron Compounds chemistry
Cell Line, Tumor
Female
Fluorescence Resonance Energy Transfer
Fluorescent Dyes chemical synthesis
Fluorescent Dyes chemistry
Hydrogen-Ion Concentration
Mice, Nude
Monitoring, Physiologic methods
Rhodamines chemical synthesis
Rhodamines chemistry
Mice
Neoplasms metabolism
Tumor Microenvironment physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1521-3773
- Volume :
- 60
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Angewandte Chemie (International ed. in English)
- Publication Type :
- Academic Journal
- Accession number :
- 33300662
- Full Text :
- https://doi.org/10.1002/anie.202012021