Back to Search
Start Over
Cross talk between human regulatory T cells and antigen-presenting cells: Lessons for clinical applications.
- Source :
-
European journal of immunology [Eur J Immunol] 2021 Jan; Vol. 51 (1), pp. 27-38. Date of Electronic Publication: 2020 Dec 23. - Publication Year :
- 2021
-
Abstract
- Regulatory T cells (Tregs) have a critical role in maintaining self-tolerance and immune homeostasis. There is much interest in using Tregs as a cell therapy to re-establish tolerance in conditions such as inflammatory bowel disease and type 1 diabetes, with many ongoing clinical studies testing the safety and efficacy of this approach. Manufacturing of Tregs for therapy typically involves ex vivo expansion to obtain sufficient cell numbers for infusion and comes with the risk of altering the activity of key biological processes. However, this process also offers an opportunity to tailor Treg function to maximize in vivo activity. In this review, we focus on the roles of antigen-presenting cells (APCs) in the generation and function of Tregs in humans. In addition to stimulating the development of Tregs, APCs activate Tregs and provide signals that induce specialized functional and homing marker expression. Cross talk between Tregs and APCs is a critical, often under-appreciated, aspect of Treg biology, with APCs mediating the key properties of infectious tolerance and bystander suppression. Understanding the biology of human Treg-APC interactions will reveal new ways to optimize Treg-based therapeutic approaches.<br /> (© 2020 Wiley-VCH GmbH.)
- Subjects :
- Cell Differentiation
Humans
Immune Tolerance
Immunological Synapses
Immunotherapy, Adoptive
Lymphocyte Activation
Models, Immunological
Receptor Cross-Talk immunology
Receptors, Lymphocyte Homing immunology
Self Tolerance
Synthetic Biology
T-Lymphocytes, Regulatory cytology
Thymus Gland cytology
Thymus Gland immunology
Antigen-Presenting Cells immunology
T-Lymphocytes, Regulatory immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1521-4141
- Volume :
- 51
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- European journal of immunology
- Publication Type :
- Academic Journal
- Accession number :
- 33301176
- Full Text :
- https://doi.org/10.1002/eji.202048746