Peniterpenoids A-C, new sesquiterpenoid metabolites from a wheat cyst nematode Penicillium janthinellum.

Authors :: Liu S
Fan W
Ren J
Wang W
Liu X
Liang Y
Wei T
Li E
Source :: Fitoterapia [Fitoterapia] 2021 Jan; Vol. 148, pp. 104801. Date of Electronic Publication: 2020 Dec 10.
Publication Year :: 2021
Abstract: Three new sesquiterpenoids, peniterpenoids A - C (1-3), together with six known metabolites (4-9) were isolated from an entomogenous fungus Penicillium janthinellum (LB1.20090001) collected from a wheat cyst nematode. The structures of the new compounds were elucidated based on NMR and HRESIMS spectroscopic analyses. The absolute configuration of the C-8 secondary alcohol of peniterpenoid B (2) was determined by [Rh <subscript>2</subscript> (OCOCF <subscript>3</subscript> ) <subscript>4</subscript> ]-induced ECD experiment. Subsequently, the antimicrobial and DPPH scavenging activities were determined. Compounds 6-8 exhibited moderate antibacterial activities against Staphylococcus aureus (CGMCC1.2465) with MIC values of 25.0, 50.0 and 12.5 μg/mL, respectively.<br /> (Copyright © 2020. Published by Elsevier B.V.)

Subjects :: Animals
Anti-Bacterial Agents isolation & purification
China
Microbial Sensitivity Tests
Molecular Structure
Sesquiterpenes isolation & purification
Staphylococcus aureus drug effects
Anti-Bacterial Agents pharmacology
Nematoda microbiology
Penicillium chemistry
Sesquiterpenes pharmacology
Triticum parasitology

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