Activation of AKT signaling via small molecule natural compound prevents against osteoblast apoptosis and osteonecrosis of the femoral head.

Authors :: Shen ZH
Hu XQ
Hu MJ
Pan XK
Lu HG
Chen B
Wu B
Chen G
Source :: American journal of translational research [Am J Transl Res] 2020 Nov 15; Vol. 12 (11), pp. 7211-7222. Date of Electronic Publication: 2020 Nov 15 (Print Publication: 2020).
Publication Year :: 2020
Abstract: Vinpocetine (Vinp), a natural compound extracted from the leaves of Phyllostachys pubescens with apoptosis modulatory properties in variety of disorders. In the present study, we investigated the possible mechanism of Vinp in alleviating of the progress of osteonecrosis of the femoral head (ONFH) both in vitro and in vivo experiments. The results showed that treatment with Vinp suppressed the dexamethasone (Dex) induced over-regulation of ROS level and apoptotic factors. Mechanistically, the Vinp activated Akt signaling pathway in osteoblast. Moreover, Vinp exerted a protective role in animal ONFH model. To summarize, this work illustrated Vinp possessed a new potential therapeutic drug in ONFH.<br />Competing Interests: None.<br /> (AJTR Copyright © 2020.)

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