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Nonclassical roles for IFN-γ and IL-10 in a murine model of immunoedition.

Authors :: Giúdice AD
Pagura L
Capitani MC
Mainetti LE
Scharovsky OG
Di Masso RJ
Rico MJ
Rozados VR
Source :: Future science OA [Future Sci OA] 2020 Oct 27; Vol. 6 (10), pp. FSO589. Date of Electronic Publication: 2020 Oct 27.
Publication Year :: 2020
Abstract: Aim: To characterize, by means of univariate and multivariate approaches, the T helper (Th)-1 and Th-2 responses during the different phases of tumor immunoediting.<br />Materials & Methods: We used a multivariate principal component analysis applied to analyze the joint behavior of serum concentrations of IFN-γ, IL-2, IL-10 and IL-4, during the different phases of tumor immunoediting, in CBi/L mice challenged with M-406 mammary adenocarcinoma.<br />Results & Conclusion: Animals in equilibrium phase showed the widest variations in values of the four cytokines. In this experimental model, the role of IFN-γ would be related to tumor growth and progression, while IL-10 would participate in the antitumor immune response.<br />Competing Interests: Financial & competing interests disclosure The work was supported by grants of Universidad Nacional de Rosario to VRR (1MED471) and Foundation AJ Roemmers. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.<br /> (© 2020 Antonela Del Giúdice.)