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CircPUM1 promotes hepatocellular carcinoma progression through the miR-1208/MAP3K2 axis.
- Source :
-
Journal of cellular and molecular medicine [J Cell Mol Med] 2021 Jan; Vol. 25 (1), pp. 600-612. Date of Electronic Publication: 2020 Dec 15. - Publication Year :
- 2021
-
Abstract
- Hepatocellular carcinoma (HCC) is a common disease with a significant mortality, and there is no effective treatment for advanced patients. Growing evidence indicates that circRNAs are closely related to HCC progression, may be used as biomarkers and targets for the diagnosis and treatment of HCC. Recent researches have shown that circPUM1 may play an oncogene role in a variety of human cancers, but its role in HCC development has not been reported. Our study found that circPUM1 could promote the proliferation, migration and invasion of HCC cells in vitro. In addition, in vivo studies showed that circPUM1 could increase the development of HCC tumours and regulate the expression of EMT-related proteins. Furthermore, we demonstrated that circPUM1 could promote the development of HCC by up-regulating the expression of MAP3K2 via sponging miR-1208. Our study suggested that circPUM1 may be a potential therapeutic target for HCC.<br /> (© 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.)
- Subjects :
- Animals
Blotting, Western
Carcinoma, Hepatocellular genetics
Gene Expression Regulation, Neoplastic genetics
Gene Expression Regulation, Neoplastic physiology
Liver Neoplasms genetics
MAP Kinase Kinase Kinase 2 genetics
Mice, Inbred BALB C
Mice, Nude
MicroRNAs genetics
RNA-Binding Proteins genetics
Mice
Carcinoma, Hepatocellular metabolism
Liver Neoplasms metabolism
MAP Kinase Kinase Kinase 2 metabolism
MicroRNAs metabolism
RNA-Binding Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1582-4934
- Volume :
- 25
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of cellular and molecular medicine
- Publication Type :
- Academic Journal
- Accession number :
- 33320435
- Full Text :
- https://doi.org/10.1111/jcmm.15998