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Concerning steric effects in antimalarial agents.
- Source :
-
Drug design and delivery [Drug Des Deliv] 1987 May; Vol. 1 (4), pp. 307-12. - Publication Year :
- 1987
-
Abstract
- Acridine, the parent nucleus of atabrine, is much more toxic than its 4,5-dimethyl derivative. The 4,5-dimethyl derivative of atabrine was therefore synthesized in the hope of producing a better-tolerated drug. The analogue was considerably more toxic than atabrine.
- Subjects :
- Acridines pharmacology
Acridines toxicity
Animals
Antimalarials toxicity
Chemical Phenomena
Chemistry
Drug Tolerance
Female
Magnetic Resonance Spectroscopy
Malaria drug therapy
Malaria parasitology
Male
Mice
Plasmodium berghei drug effects
Quinacrine chemical synthesis
Quinacrine pharmacology
Quinacrine toxicity
Acridines chemical synthesis
Antimalarials chemical synthesis
Quinacrine analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0884-2884
- Volume :
- 1
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Drug design and delivery
- Publication Type :
- Academic Journal
- Accession number :
- 3334542