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Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection.
- Source :
-
Science immunology [Sci Immunol] 2020 Dec 23; Vol. 5 (54). - Publication Year :
- 2020
-
Abstract
- Understanding the nature of immunity following mild/asymptomatic infection with SARS-CoV-2 is crucial to controlling the pandemic. We analyzed T cell and neutralizing antibody responses in 136 healthcare workers (HCW) 16-18 weeks after United Kingdom lockdown, 76 of whom had mild/asymptomatic SARS-CoV-2 infection captured by serial sampling. Neutralizing antibodies (nAb) were present in 89% of previously infected HCW. T cell responses tended to be lower following asymptomatic infection than in those reporting case-definition symptoms of COVID-19, while nAb titers were maintained irrespective of symptoms. T cell and antibody responses were sometimes discordant. Eleven percent lacked nAb and had undetectable T cell responses to spike protein but had T cells reactive with other SARS-CoV-2 antigens. Our findings suggest that the majority of individuals with mild or asymptomatic SARS-CoV-2 infection carry nAb complemented by multispecific T cell responses at 16-18 weeks after mild or asymptomatic SARS-CoV-2 infection.<br /> (Copyright © 2020, American Association for the Advancement of Science.)
Details
- Language :
- English
- ISSN :
- 2470-9468
- Volume :
- 5
- Issue :
- 54
- Database :
- MEDLINE
- Journal :
- Science immunology
- Publication Type :
- Academic Journal
- Accession number :
- 33361161
- Full Text :
- https://doi.org/10.1126/sciimmunol.abf3698