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Salicylaldehyde derivatives from a marine-derived fungus Eurotium sp. SCSIO F452.
- Source :
-
The Journal of antibiotics [J Antibiot (Tokyo)] 2021 Apr; Vol. 74 (4), pp. 273-279. Date of Electronic Publication: 2020 Dec 23. - Publication Year :
- 2021
-
Abstract
- Two pairs of new salicylaldehyde derivative enantiomers, salicylaldehydiums A and B (1 and 2), along with five known analogues were isolated and identified from a marine-derived fungus Eurotium sp. SCSIO F452. Their structures and absolute configuration were determined by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculations. All the new optical pure enantiomers [(+)-1, (-)-1, (+)-2, (-)-2] were evaluated for their cytotoxic and antioxidative activities. Compound (-)-1 exhibited weak cytotoxic activity.
- Subjects :
- Aldehydes metabolism
Antioxidants chemistry
Aquatic Organisms
Circular Dichroism
Drug Evaluation, Preclinical
Hep G2 Cells
Humans
Magnetic Resonance Spectroscopy
Molecular Structure
Spectrometry, Mass, Electrospray Ionization
Stereoisomerism
Aldehydes chemistry
Aldehydes pharmacology
Antioxidants pharmacology
Eurotium chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1881-1469
- Volume :
- 74
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Journal of antibiotics
- Publication Type :
- Academic Journal
- Accession number :
- 33361799
- Full Text :
- https://doi.org/10.1038/s41429-020-00395-x