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ENDOCRINE REGULATION OF ERYTHROID LINEAGE OF HEMATOPOIESIS IN CHILDREN LIVING UNDER A LOW-DOSE RADIATION EXPOSURE AFTER THE CHORNOBYL NPP ACCIDENT.
- Source :
-
Problemy radiatsiinoi medytsyny ta radiobiolohii [Probl Radiac Med Radiobiol] 2020 Dec; Vol. 25, pp. 374-389. - Publication Year :
- 2020
-
Abstract
- Objective: Elucidation of relationship between the levels of thyroid-stimulating hormone (TSH), free serum thyroxine, serum and urine cortisol and parameters of erythroid lineage of hematopoiesis to estimate the thyroid functionin children of prepubertal, pubertal, and postpubertal age permanently residing under a low-dose radiation exposureto determine the premorbid state of thyroid function.<br />Materials and Methods: Children aged 3 to 18 years old (n = 203) living in the most intensively radionuclide-contaminated regions of Kyiv, Zhytomyr and Chornihiv oblasts of Ukraine after the Chornobyl NPP accident wereenrolled. Complaints of ossalgia, arthralgia, fatigue, bone fractures in the history, bone dysembryogenetic stigmata,hypermobility syndrome degree, and types of somatic diseases were taken into account. Peripheral blood countparameters, biochemical indices of blood serum were studied, namely the levels of total protein, cholesterol, creatinine and alkaline phosphatase activity. Levels of the free thyroxine, pituitary TSH, serum and daily urine cortisol, anddoses of radiation exposure were determined.<br />Results: The radiation dose values in children ranged from (0.35 ± 0.09) mSv to (0.54 ± 0.12) mSv. There was nodifference between the parameters of erythroid lineage of hematopoiesis depending on radiation dose. At the levels of serum TSH up to 1.0 μIU/ml no correlation was found with cortisol levels; at TSH levels of 1.0-3.0 μIU/ml thecorrelation coefficient was r = 0.31; at TSH levels higher than 3.0 μIU/ml the correlation coefficient was r = 0.61probably indicating a compensatory role of adrenal cortex in children at risk of thyroid disease development. In children with joint hypermobility grade II there was a higher incidence of dentofacial anomalies (χ2 = 6.9), deformitiesof lower extremities (χ2 = 6.9), and dental caries (χ2 = 4.3) (p < 0.05). There was a direct correlation between theserum TSH level (over 3 μIU/ml) and micrognathia (brachygnathia) (r = 0.62) indicating the impact of thyroid disease on dentofacial development. The TSH at a level of upper limit of the reference range values may contribute toa decreased RBC count in peripheral blood, increased average volume and hemoglobin content in erythrocyte beingassociated with the initial manifestations of thyroid dysfunction.<br />Conclusions: Abnormal endocrine regulation of hematopoiesis affects the connective tissue, stromal microenvironment of bone marrow, and accordingly the erythroid branch of hematopoiesis in children, which may be relevant inthe development and course of oncohematological diseases.<br /> (V. G. Bebeshko, K. M. Bruslova, O. Y. Boyarska, L.O. Lyashenko, N. M. Tsvyetkova, L. O. Gonchar, T. O. Chernysh, I. V. Trychlib, V. D. Pismenniy, Z. S. Yaroshenko, V. V. Vasylenko.)
- Subjects :
- Adolescent
Arthralgia blood
Arthralgia etiology
Arthralgia pathology
Cell Lineage radiation effects
Child
Child, Preschool
Dental Caries blood
Dental Caries etiology
Dental Caries pathology
Erythroid Cells pathology
Erythroid Cells radiation effects
Fatigue blood
Fatigue etiology
Fatigue pathology
Female
Fractures, Bone blood
Fractures, Bone etiology
Fractures, Bone pathology
Humans
Hydrocortisone urine
Joint Instability blood
Joint Instability etiology
Joint Instability pathology
Male
Puberty blood
Puberty radiation effects
Radiation Dosage
Radiation Exposure adverse effects
Radiation, Ionizing
Radioisotopes
Thyroid Gland pathology
Thyroid Gland radiation effects
Thyrotropin blood
Thyroxine blood
Ukraine epidemiology
Arthralgia epidemiology
Chernobyl Nuclear Accident
Dental Caries epidemiology
Fatigue epidemiology
Fractures, Bone epidemiology
Hematopoiesis radiation effects
Joint Instability epidemiology
Subjects
Details
- Language :
- English; Ukrainian
- ISSN :
- 2313-4607
- Volume :
- 25
- Database :
- MEDLINE
- Journal :
- Problemy radiatsiinoi medytsyny ta radiobiolohii
- Publication Type :
- Academic Journal
- Accession number :
- 33361848
- Full Text :
- https://doi.org/10.33145/2304-8336-2020-25-374-389