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Prolonged SARS-CoV-2 viral shedding in patients with chronic kidney disease.
- Source :
-
Nephrology (Carlton, Vic.) [Nephrology (Carlton)] 2021 Apr; Vol. 26 (4), pp. 328-332. Date of Electronic Publication: 2020 Dec 23. - Publication Year :
- 2021
-
Abstract
- Recent World Health Organization guidance has aimed to provide pragmatic guidance acknowledging the role of sequential nasopharyngeal swabs taken >24 hours apart for SARS-CoV-2 in high-risk populations. Patients with chronic kidney disease (CKD) are known to have an altered immune milieu which may be associated with a delay in viral clearance. Here, a cross-sectional observational study of 138 patients admitted with SARS-CoV-2 infection at two large regional hospitals in Scotland, UK examined the median time to two consecutive negative nasopharyngeal swabs for SARS-CoV-2 in an inpatient population. The median time from admission to the first of two consecutive negative nasopharyngeal swabs was 18 days (range = 1-44) in patients with CKD, compared with 11 days (range: 1-71) in patients without CKD (P = .0007). Multivariable linear regression analysis using explanatory variables of age, sex, SARS-CoV-2 disease severity, key comorbidities and renal function showed that declining estimated glomerular filtration rate was independently associated with prolonged time to viral clearance. Our data suggest that patients with CKD who are admitted to hospital with SARS-CoV-2 take longer to achieve sequential negative nasopharyngeal swab reverse transcription-polymerase chain reaction results than those without CKD. This has implications for renal service provision, discharge planning and hospital capacity as well as a direct impact on patients due to extended hospital stay, anxiety and stigmatisation.<br /> (© 2020 Asian Pacific Society of Nephrology.)
- Subjects :
- Aged
Aged, 80 and over
COVID-19 complications
COVID-19 therapy
Cross-Sectional Studies
Female
Glomerular Filtration Rate
Hospitalization
Humans
Linear Models
Male
Middle Aged
Renal Insufficiency, Chronic therapy
Renal Insufficiency, Chronic virology
Reverse Transcriptase Polymerase Chain Reaction
Scotland
Time Factors
COVID-19 diagnosis
COVID-19 Nucleic Acid Testing
Renal Insufficiency, Chronic complications
SARS-CoV-2 physiology
Virus Shedding
Subjects
Details
- Language :
- English
- ISSN :
- 1440-1797
- Volume :
- 26
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Nephrology (Carlton, Vic.)
- Publication Type :
- Academic Journal
- Accession number :
- 33368892
- Full Text :
- https://doi.org/10.1111/nep.13844