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Scurvy presenting as lower limb ecchymoses in the setting of metastatic colorectal cancer.
- Source :
-
BMJ case reports [BMJ Case Rep] 2020 Dec 18; Vol. 13 (12). Date of Electronic Publication: 2020 Dec 18. - Publication Year :
- 2020
-
Abstract
- A 58-year-old woman presented with a 1-week history of lower limb bruising. She had a medical history of recurrent metastatic colon cancer with a sigmoid colectomy and complete pelvic exenteration leading to colostomy and urostomy formation. She had malignant sacral mass encroaching on the spinal cord. This caused a left-sided foot drop for which she used an ankle-foot orthosis. She was on cetuximab and had received radiotherapy to the sacral mass 1 month ago. On examination, there were macular ecchymoses with petechiae on the lower limbs. There was sparing of areas that had been compressed by the ankle-foot orthosis. Bloods showed mild thrombocytopaenia and anaemia with markedly raised inflammatory markers. Coagulation studies consistent with inflammation rather than disseminated intravascular coagulation. She was found to have Klebsiella bacteraemia secondary to urinary source. Skin biopsy showed dermal haemorrhage without vessel inflammation. Vitamin C levels were low confirming the diagnosis of scurvy.<br />Competing Interests: Competing interests: None declared.<br /> (© BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ.)
- Subjects :
- Antineoplastic Agents, Immunological therapeutic use
Bacteremia diagnosis
Bacteremia microbiology
Colectomy methods
Diagnosis, Differential
Female
Humans
Klebsiella isolation & purification
Lower Extremity
Middle Aged
Neoplasm Metastasis
Neoplasm Staging
Pelvic Exenteration adverse effects
Pelvic Exenteration methods
Skin pathology
Treatment Outcome
Vitamins administration & dosage
Ascorbic Acid administration & dosage
Ascorbic Acid blood
Colectomy adverse effects
Colorectal Neoplasms pathology
Colorectal Neoplasms physiopathology
Colorectal Neoplasms secondary
Colorectal Neoplasms therapy
Ecchymosis blood
Ecchymosis diagnosis
Ecchymosis etiology
Malnutrition etiology
Malnutrition therapy
Nutritional Support methods
Scurvy blood
Scurvy etiology
Scurvy physiopathology
Scurvy therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1757-790X
- Volume :
- 13
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- BMJ case reports
- Publication Type :
- Academic Journal
- Accession number :
- 33370932
- Full Text :
- https://doi.org/10.1136/bcr-2020-237507