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Chimeric RNA ASTN2-PAPPA as aggravates tumor progression and metastasis in human esophageal cancer.
- Source :
-
Cancer letters [Cancer Lett] 2021 Mar 31; Vol. 501, pp. 1-11. Date of Electronic Publication: 2020 Dec 31. - Publication Year :
- 2021
-
Abstract
- Transcription-induced chimeric RNAs are an emerging area of research into molecular signatures for disease biomarker and therapeutic target development. Despite their importance, little is known for chimeric RNAs-relevant roles and the underlying mechanisms for cancer pathogenesis and progression. Here we describe a unique ASTN2-PAPPA <subscript>antisense</subscript> chimeric RNA (A-P <subscript>as</subscript> chiRNA) that could be the first reported chimeric RNA derived from the splicing of exons and intron antisense of two neighboring genes, respectively. Aberrant A-P <subscript>as</subscript> chiRNA level in ESCC tissues was associated with tumor progression and patients' outcome. In vitro and in vivo studies demonstrated that A-P <subscript>as</subscript> chiRNA aggravated ESCC metastasis and enhanced stemness through modulating OCT4. Mechanistic studies demonstrated that ERK5-mediated non-canonical PAF1 activity was required for A-P <subscript>as</subscript> chiRNA-induced cancer malignancy. The study defined an undocumented function of chimeric RNAs in aggravating cancer stemness and metastasis.<br /> (Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Disease Progression
Esophageal Neoplasms metabolism
Esophageal Neoplasms pathology
Esophageal Squamous Cell Carcinoma metabolism
Esophageal Squamous Cell Carcinoma pathology
Female
Humans
Lymphatic Metastasis
Male
Middle Aged
Mitogen-Activated Protein Kinase 7 genetics
Mitogen-Activated Protein Kinase 7 metabolism
Neoplasm Metastasis
Neoplastic Stem Cells pathology
RNA genetics
Transcription Factors genetics
Transcription Factors metabolism
Esophageal Neoplasms genetics
Esophageal Squamous Cell Carcinoma genetics
Glycoproteins genetics
Nerve Tissue Proteins genetics
Pregnancy-Associated Plasma Protein-A genetics
RNA, Messenger genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7980
- Volume :
- 501
- Database :
- MEDLINE
- Journal :
- Cancer letters
- Publication Type :
- Academic Journal
- Accession number :
- 33388371
- Full Text :
- https://doi.org/10.1016/j.canlet.2020.10.052