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A review on mechanism of inhibition of advanced glycation end products formation by plant derived polyphenolic compounds.
- Source :
-
Molecular biology reports [Mol Biol Rep] 2021 Jan; Vol. 48 (1), pp. 787-805. Date of Electronic Publication: 2021 Jan 03. - Publication Year :
- 2021
-
Abstract
- Advanced glycation end products (AGEs) are naturally occurring biomolecules formed by interaction of reducing sugars with biomolecules such as protein and lipids etc., Long term high blood sugar level and glycation accelerate the formation of AGEs. Unchecked continuous formation and accumulation of AGEs are potential risks for pathogenesis of various chronic diseases. Current mode of antidiabetic therapy is based on synthetic drugs that are often linked with severe adverse effects. Polyphenolic compounds derived from plants are supposed to inhibit glycation and formation of AGEs at multiple levels. Some polyphenolic compounds regulate the blood glucose metabolism by amplification of cell insulin resistance and activation of insulin like growth factor binding protein signaling pathway. Their antioxidant nature and metal chelating activity, ability to trap intermediate dicarbonyl compounds could be possible mechanisms against glycation and AGEs formation and hence, against AGEs induced health complications. Although, few species of polyphenolic compounds are being used in in vitro trials and their in vivo study is still in progress, increasing the area of research in this field may produce a fruitful approach in management of overall diabetic complications.
- Subjects :
- Blood Glucose metabolism
Diabetes Mellitus genetics
Diabetes Mellitus metabolism
Diabetes Mellitus pathology
Gene Expression Regulation
Glycation End Products, Advanced genetics
Glycation End Products, Advanced metabolism
Glycosylation
Humans
Insulin Resistance
Insulin-Like Growth Factor Binding Protein 1 genetics
Insulin-Like Growth Factor Binding Protein 1 metabolism
Obesity genetics
Obesity metabolism
Obesity pathology
Signal Transduction
Antioxidants therapeutic use
Diabetes Mellitus drug therapy
Glycation End Products, Advanced antagonists & inhibitors
Hypoglycemic Agents therapeutic use
Obesity drug therapy
Phytochemicals therapeutic use
Polyphenols therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1573-4978
- Volume :
- 48
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Molecular biology reports
- Publication Type :
- Academic Journal
- Accession number :
- 33389535
- Full Text :
- https://doi.org/10.1007/s11033-020-06084-0