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Sodium dehydroacetate induces cardiovascular toxicity associated with Ca 2+ imbalance in zebrafish.
- Source :
-
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2021 Jan 15; Vol. 208, pp. 111613. Date of Electronic Publication: 2020 Nov 09. - Publication Year :
- 2021
-
Abstract
- The environmental effects of additives have attracted increasing attention. Sodium dehydroacetate (DHA-S), as an approved preservative, is widely added in processed foods, cosmetics and personal care products. However, DHA-S has been recently reported to induce hemorrhage and coagulation aberration in rats. Yet little is known about the ecotoxicological effect and underlying mechanisms of DHA-S. Here, we utilized the advantage of zebrafish model to evaluate such effects. DHA-S induced cerebral hemorrhage, mandibular dysplasia and pericardial edema in zebrafish after 24 h exposure (48-72 hpf) at 50 mg/L. We also observed the defective heart looping and apoptosis in DHA-S-treated zebrafish through o-dianisidine and acridine orange staining. Meanwhile, DHA-S induced the deficiency of Ca <superscript>2+</superscript> and vitamin D3 in zebrafish. We further demonstrated that DHA-S stimulated Ca <superscript>2+</superscript> influx resulting in Ca <superscript>2+</superscript> -dependent mitochondrial damage in cardiomyocytes. Additionally, DHA-S inhibited glucose uptake and repressed the biosynthesis of amino acids. Finally, we identified that sodium bicarbonate could rescue zebrafish from DHA-S induced cardiovascular toxicity. Altogether, our results suggest that DHA-S is a potential risk for cardiovascular system.<br /> (Copyright © 2020. Published by Elsevier Inc.)
- Subjects :
- Animals
Apoptosis drug effects
Cardiotoxicity
Cell Line
Cerebral Hemorrhage chemically induced
Dose-Response Relationship, Drug
Edema, Cardiac chemically induced
Heart embryology
Myocardium metabolism
Myocardium pathology
Pericardium drug effects
Pericardium pathology
Rats
Calcium metabolism
Embryo, Nonmammalian drug effects
Embryonic Development drug effects
Heart drug effects
Pyrones toxicity
Zebrafish growth & development
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2414
- Volume :
- 208
- Database :
- MEDLINE
- Journal :
- Ecotoxicology and environmental safety
- Publication Type :
- Academic Journal
- Accession number :
- 33396133
- Full Text :
- https://doi.org/10.1016/j.ecoenv.2020.111613