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Genome-wide association study of body size traits in Wenshang Barred chickens based on the specific-locus amplified fragment sequencing technology.
- Source :
-
Animal science journal = Nihon chikusan Gakkaiho [Anim Sci J] 2021 Jan-Dec; Vol. 92 (1), pp. e13506. - Publication Year :
- 2021
-
Abstract
- Chicken body size (BS) is an economically important trait, which has been assessed in many studies for genetic selection. However, previous reports detected functional chromosome mutations or regions using gene chips. The present study used the specific-locus amplified fragment sequencing (SLAF-seq) technology to perform a genome-wide association study (GWAS) of purebred Wenshang Barred chickens. A total of 250 one-day-old male chickens were assessed in this study. Body size in individual birds was measured at 56 days. SLAF-seq was used to genotype and GWAS analysis was carried out using the general linear model (GLM) of the TASSEL program. A total of 1,286,715 single-nucleotide polymorphisms (SNPs) were detected, of which 175,211 were tested as candidate SNPs for genome-wide association analysis using the TASSEL general linear model. Three SNPs markers reached genome-wide significance. Of these, chrZ:81729634, chrZ:81841715, and chrZ:81954149 at 81,729,634, 81,841,715, and 81,954,149 bp of GGA Z were significantly associated with body diagonal length at 56 days (BDL56); and tibia length at 56 days (TL56). These SNPs were close to three genes, including ZCCHC7, PAX5, and MELK. These results open new horizons for studies on BS and should promote the use of Chinese chickens, especially Wenshang Barred chickens.<br /> (© 2021 Japanese Society of Animal Science.)
- Subjects :
- Animals
Male
PAX5 Transcription Factor genetics
Polymorphism, Single Nucleotide genetics
Protein Serine-Threonine Kinases genetics
Transcription Factors genetics
Body Size genetics
Chickens genetics
Genome-Wide Association Study methods
Genotyping Techniques methods
Quantitative Trait, Heritable
Subjects
Details
- Language :
- English
- ISSN :
- 1740-0929
- Volume :
- 92
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Animal science journal = Nihon chikusan Gakkaiho
- Publication Type :
- Academic Journal
- Accession number :
- 33398896
- Full Text :
- https://doi.org/10.1111/asj.13506