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Antibiotic resistance and persistence-Implications for human health and treatment perspectives.
- Source :
-
EMBO reports [EMBO Rep] 2020 Dec 03; Vol. 21 (12), pp. e51034. Date of Electronic Publication: 2020 Dec 08. - Publication Year :
- 2020
-
Abstract
- Antimicrobial resistance (AMR) and persistence are associated with an elevated risk of treatment failure and relapsing infections. They are thus important drivers of increased morbidity and mortality rates resulting in growing healthcare costs. Antibiotic resistance is readily identifiable with standard microbiological assays, and the threat imposed by antibiotic resistance has been well recognized. Measures aiming to reduce resistance development and spreading of resistant bacteria are being enforced. However, the phenomenon of bacteria surviving antibiotic exposure despite being fully susceptible, so-called antibiotic persistence, is still largely underestimated. In contrast to antibiotic resistance, antibiotic persistence is difficult to measure and therefore often missed, potentially leading to treatment failures. In this review, we focus on bacterial mechanisms allowing evasion of antibiotic killing and discuss their implications on human health. We describe the relationship between antibiotic persistence and bacterial heterogeneity and discuss recent studies that link bacterial persistence and tolerance with the evolution of antibiotic resistance. Finally, we review persister detection methods, novel strategies aiming at eradicating bacterial persisters and the latest advances in the development of new antibiotics.<br /> (© 2020 The Authors.)
Details
- Language :
- English
- ISSN :
- 1469-3178
- Volume :
- 21
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- EMBO reports
- Publication Type :
- Academic Journal
- Accession number :
- 33400359
- Full Text :
- https://doi.org/10.15252/embr.202051034