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Progesterone levels predict pregnancy outcomes in individuals with fallopian tube associated infertility.
- Source :
-
BMC pregnancy and childbirth [BMC Pregnancy Childbirth] 2021 Jan 06; Vol. 21 (1), pp. 16. Date of Electronic Publication: 2021 Jan 06. - Publication Year :
- 2021
-
Abstract
- Background: This study aimed at determining the predictive value of human chorionic gonadotropin and progesterone levels on pregnancy outcomes in patients receiving in vitro fertilization due to fallopian tube associated infertility.<br />Methods: We retrospectively analyzed the clinical data of 854 cycles due to fallopian tube associated infertility in vitro fertilization fresh embryo transfer. The clinical data had been collected from January 2010 to December 2018 and was divided into 7 groups depending on the progesterone level on human chorionic gonadotropin administration day. Live birth rates and observation trends were calculated. The receiver operating characteristic curve was established to determine the optimal cutoff value for progesterone, which was used to further divide the data into 3 groups; Group 1 (progesterone ≦ 1.0 ng/ml), Group 2 (1.0 ng/ml ≤ progesterone ≤ 1.25 ng/ml), and Group 3 (progesterone ≥ 1.25 ng/ml). We then compared the ovulation results and clinical outcomes among the 3 groups.<br />Results: There were no significant differences in age, infertility years, gonadotropin dosage, gonadotropin days, Luteinizing hormone level on human chorionic gonadotropin day, 2 pronuclear fertilization rates, clinical pregnancy rates, live birth rates, full-term birth rate, and preterm birth rates among the three groups. However body mass index (p = 0.001), basal luteinizing hormone (p = 0.034), estrogen peak (p < 0.001), number of oocytes obtained (P < 0.001) were significantly different.<br />Conclusions: Progesterone level on human chorionic gonadotropin day does not affect the clinical pregnancy rate and live birth rates after in vitro fertilization. However, progesterone levels between 1.0 and 1.25 ng/ml may lead to good clinical pregnancy outcomes.
- Subjects :
- Adult
Chorionic Gonadotropin administration & dosage
Embryo Transfer
Female
Humans
Infertility, Female etiology
Live Birth
Pregnancy
Pregnancy Rate
ROC Curve
Retrospective Studies
Fallopian Tube Diseases complications
Fertilization in Vitro
Infertility, Female therapy
Pregnancy Outcome
Progesterone blood
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2393
- Volume :
- 21
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC pregnancy and childbirth
- Publication Type :
- Academic Journal
- Accession number :
- 33407250
- Full Text :
- https://doi.org/10.1186/s12884-020-03495-6