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MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor-1.
- Source :
-
ELife [Elife] 2021 Jan 08; Vol. 10. Date of Electronic Publication: 2021 Jan 08. - Publication Year :
- 2021
-
Abstract
- The oncoprotein transcription factor MYC is a major driver of malignancy and a highly validated but challenging target for the development of anticancer therapies. Novel strategies to inhibit MYC may come from understanding the co-factors it uses to drive pro-tumorigenic gene expression programs, providing their role in MYC activity is understood. Here we interrogate how one MYC co-factor, host cell factor (HCF)-1, contributes to MYC activity in a human Burkitt lymphoma setting. We identify genes connected to mitochondrial function and ribosome biogenesis as direct MYC/HCF-1 targets and demonstrate how modulation of the MYC-HCF-1 interaction influences cell growth, metabolite profiles, global gene expression patterns, and tumor growth in vivo. This work defines HCF-1 as a critical MYC co-factor, places the MYC-HCF-1 interaction in biological context, and highlights HCF-1 as a focal point for development of novel anti-MYC therapies.<br />Competing Interests: TP, JW, CA, GH, SC, SS, JM, LT, SL, YM, AW, CE, QL, WT No competing interests declared<br /> (© 2021, Popay et al.)
Details
- Language :
- English
- ISSN :
- 2050-084X
- Volume :
- 10
- Database :
- MEDLINE
- Journal :
- ELife
- Publication Type :
- Academic Journal
- Accession number :
- 33416496
- Full Text :
- https://doi.org/10.7554/eLife.60191