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The role of Mrgprs in pain.
- Source :
-
Neuroscience letters [Neurosci Lett] 2021 Jan 23; Vol. 744, pp. 135544. Date of Electronic Publication: 2021 Jan 06. - Publication Year :
- 2021
-
Abstract
- Owing to their functional diversity, the Mas-related G-protein-coupled receptor (Mrgpr) family has a role in both itch and pain modulation. While primarily linked to pruritis, Mrgprs were originally characterized in small-diameter nociceptive neurons of dorsal root ganglia (DRG) and trigeminal ganglia. This review will focus on the role Mrgpr's have in pain physiology, discussing recent discoveries as well as how Mrgpr's may provide a new target for the treatment of pathological pain.<br /> (Copyright © 2021 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Ganglia, Spinal metabolism
Ganglia, Spinal pathology
Humans
Mast Cells metabolism
Nociceptors pathology
Pain diagnosis
Pain Management methods
Sensory Receptor Cells metabolism
Sensory Receptor Cells pathology
Nociceptors metabolism
Pain metabolism
Receptors, G-Protein-Coupled metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7972
- Volume :
- 744
- Database :
- MEDLINE
- Journal :
- Neuroscience letters
- Publication Type :
- Academic Journal
- Accession number :
- 33421487
- Full Text :
- https://doi.org/10.1016/j.neulet.2020.135544