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A considerable asymptomatic proportion and thromboembolism risk of pregnant women with COVID-19 infection in Wuhan, China.
- Source :
-
Journal of perinatal medicine [J Perinat Med] 2020 Nov 23; Vol. 49 (2), pp. 237-240. Date of Electronic Publication: 2020 Nov 23 (Print Publication: 2021). - Publication Year :
- 2020
-
Abstract
- Objectives: The coronavirus disease 2019 (COVID-19) had become a worldwide pandemic, however, information is limited on the asymptomatic proportion and thromboembolism risk of pregnant women with infection.<br />Methods: All 32 pregnant women with COVID-19 who were admitted to the hospital in Wuhan during the outbreak from January 20 to March 18, 2020, were retrospectively reviewed for the clinical records, laboratory tests, chest CT scans, and neonatal outcomes.<br />Results: There were 17 of the 32 patients (53%) with no subjective symptoms before admission, and 13 (41%) remained asymptomatic throughout hospitalization. There were 28 patients (88%) showing typical radiographic evidence of pneumonia on chest CT. The patients with COVID-19 were found in an increased risk of thromboembolism with much higher D-dimer levels than uninfected pregnant women. One neonate with asphyxia and positive immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies was reported.<br />Conclusions: The considerable asymptomatic proportion of pregnant women with COVID-19 indicates symptom-based screening would miss a number of cases. Chest CT could provide a useful screening resource during the COVID-19epidemic outbreak. Anticoagulation therapy for the postpartum patients may be helpful for good prognosis. The findings provide important information for the hospital isolation, control strategies and clinical therapy.<br /> (© 2020 Walter de Gruyter GmbH, Berlin/Boston.)
- Subjects :
- Adult
COVID-19 blood
COVID-19 diagnostic imaging
COVID-19 epidemiology
China epidemiology
Female
Fibrin Fibrinogen Degradation Products metabolism
Humans
Infant, Newborn
Pregnancy
Pregnancy Complications, Infectious blood
Pregnancy Complications, Infectious diagnostic imaging
Pregnancy Complications, Infectious epidemiology
Radiography, Thoracic
Retrospective Studies
Tomography, X-Ray Computed
Young Adult
Asymptomatic Infections epidemiology
COVID-19 complications
Pregnancy Complications, Infectious virology
Thromboembolism virology
Subjects
Details
- Language :
- English
- ISSN :
- 1619-3997
- Volume :
- 49
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of perinatal medicine
- Publication Type :
- Academic Journal
- Accession number :
- 33470960
- Full Text :
- https://doi.org/10.1515/jpm-2020-0409