Back to Search Start Over

Pre-clinical evaluation of the effect of a volume-stable collagen matrix on periodontal regeneration in two-wall intrabony defects.

Authors :
Imber JC
Bosshardt DD
Stähli A
Saulacic N
Deschner J
Sculean A
Source :
Journal of clinical periodontology [J Clin Periodontol] 2021 Apr; Vol. 48 (4), pp. 560-569. Date of Electronic Publication: 2021 Feb 01.
Publication Year :
2021

Abstract

Aim: To histologically evaluate the effect of a new collagen matrix on periodontal regeneration.<br />Materials and Methods: Two-wall intrabony defects were surgically created bilaterally distally to the maxillary first and third pre-molars in beagle dogs. The defects were randomly allocated to open flap debridement either with (test) or without (control) a volume-stable collagen matrix (VCMX). After 12 weeks, the dogs were euthanized, and the specimens histologically processed. Descriptive, histomorphometrical (vertical gain of periodontal tissues) and statistical analyses were then performed.<br />Results: Healing was uneventful in most cases. Residual VCMX was still present and showed integration into new bone, new periodontal ligament, connective tissue and, in some specimens, into new cementum. Periodontal regeneration occurred to a varying extent in both groups. New continuous cementum and new bone formation were statistically significantly greater in the test group (4.12 mm and 3.28 mm, respectively) than in the control group (1.54 mm and 2.47 mm, respectively) (p = .009 and p = .037, respectively). The junctional epithelium was longer in the control group (2.21 mm) than in the test group (1.49 mm, p = .16).<br />Conclusion: The present results have for the first time provided histologic evidence for the potential of this novel VCMX to facilitate periodontal regeneration thus warranting further pre-clinical and clinical testing.<br /> (© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Details

Language :
English
ISSN :
1600-051X
Volume :
48
Issue :
4
Database :
MEDLINE
Journal :
Journal of clinical periodontology
Publication Type :
Academic Journal
Accession number :
33471389
Full Text :
https://doi.org/10.1111/jcpe.13426