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Ocular lamellar crystalline gels for sustained release and enhanced permeation of resveratrol against corneal neovascularization.
- Source :
-
Drug delivery [Drug Deliv] 2021 Dec; Vol. 28 (1), pp. 206-217. - Publication Year :
- 2021
-
Abstract
- Corneal neovascularization (CNV) is the major cause of blindness after eye injury; however, only several drugs can be applied and the invasive administration ways (i.e., intravitreal injection and subconjunctival injection) are used. Resveratrol is a highly effective anti-VEGF agent against CNV. However, its applications are limited due to its strong hydrophobicity and instability. Here, we developed a resveratrol-loaded ocular lamellar crystalline gel (ROLG) for high inhibition of CNV. ROLGs were composed of resveratrol, glyceryl monooleate (GMO), ethanol, and water, and their lamellar crystalline structures were identified by polarizing light microscopy and small-angle X-ray scattering. High drug loading (4.4 mg/g) of ROLGs was achieved due to the hydrogen bonding between GMO and resveratrol. Resveratrol showed sustained release with 67% accumulative release in 7 h, which was attributed to the slow erosion of gels. Resveratrol in ROLGs had a high corneal permeation 3 times higher than resveratrol in hyaluronic acid suspensions (RHSs). ROLGs were administered to rats only once a day because of their strong retention on the cornea surface. ROLGs were safe due to the very little contact of ethanol in ROLGs to the cornea. CNV post-rat corneal alkaline injury was highly inhibited by ROLGs, resulting from the attenuation of corneal VEGF expression and then corneal healing was improved. The ROLG was a promising ocular medicine for the prevention of CNV.
- Subjects :
- Administration, Ophthalmic
Animals
Burns, Chemical metabolism
Burns, Chemical pathology
Cell Line
Computer Simulation
Corneal Injuries chemically induced
Corneal Injuries metabolism
Corneal Injuries pathology
Corneal Neovascularization metabolism
Corneal Neovascularization pathology
Crystallization
Delayed-Action Preparations
Drug Carriers
Drug Liberation
Enzyme Inhibitors pharmacology
Epithelial Cells drug effects
Epithelium, Corneal cytology
Epithelium, Corneal drug effects
Ethanol
Eye Burns chemically induced
Eye Burns metabolism
Eye Burns pathology
Glycerides
Humans
In Vitro Techniques
Molecular Docking Simulation
Ocular Absorption
Powder Diffraction
Rats
Resveratrol pharmacology
Scattering, Small Angle
Spectroscopy, Fourier Transform Infrared
Tomography, Optical Coherence
Vascular Endothelial Growth Factor A metabolism
Water
Corneal Neovascularization prevention & control
Enzyme Inhibitors administration & dosage
Gels
Liquid Crystals
Resveratrol administration & dosage
Vascular Endothelial Growth Factor A drug effects
Wound Healing drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1521-0464
- Volume :
- 28
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Drug delivery
- Publication Type :
- Academic Journal
- Accession number :
- 33472443
- Full Text :
- https://doi.org/10.1080/10717544.2021.1872739