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Cumulative incidence of solid and hematological De novo malignancy after liver transplantation in a multicentre cohort.
- Source :
-
Annals of hepatology [Ann Hepatol] 2021 Sep-Oct; Vol. 24, pp. 100309. Date of Electronic Publication: 2021 Jan 20. - Publication Year :
- 2021
-
Abstract
- Background: Recent innovations in the field of liver transplantation have led to a wealth of new treatment regimes, with potential impact on the onset of de novo malignancies (DNM). The aim of this multicenter cohort study was to provide contemporary figures for the cumulative incidences of solid and hematological DNM after liver transplantation.<br />Methods: We designed a retrospective cohort study including patients undergoing LT between 2000 and 2015 in three Italian transplant centers. Cumulative incidence was calculated by Kaplan-Meyer analysis.<br />Results: The study included 789 LT patients with a median follow-up of 81 months (IQR: 38-124). The cumulative incidence of non-cutaneous DNM was 6.2% at 5-years, 11.6% at 10-years and 16.3% at 15-years. Post-Transplant Lymphoproliferative Disorders (PTLD) were demonstrated to have a cumulative incidence of 1.0% at 5-years, 1.6% at 10-years and 2.2% at 15-years. Solid Organ Tumors (SOT) demonstrated higher cumulative incidences - 5.3% at 5-years, 10.3% at 10-years and 14.4% at 15-years. The most frequently observed classifications of SOT were lung (rate 1.0% at 5-years, 2.5% at 10-years) and head & neck tumors (rate 1.3% at 5-years, 1.9% at 10-years).<br />Conclusions: Lung tumors and head & neck tumors are the most frequently observed SOT after LT.<br /> (Copyright © 2021 Fundación Clínica Médica Sur, A.C. Published by Elsevier España, S.L.U. All rights reserved.)
- Subjects :
- Adolescent
Adult
Aged
Female
Humans
Incidence
Italy
Kaplan-Meier Estimate
Liver Diseases etiology
Liver Diseases pathology
Male
Middle Aged
Neoplasms diagnosis
Postoperative Complications diagnosis
Proportional Hazards Models
Retrospective Studies
Young Adult
Liver Diseases surgery
Liver Transplantation
Neoplasms epidemiology
Postoperative Complications epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1665-2681
- Volume :
- 24
- Database :
- MEDLINE
- Journal :
- Annals of hepatology
- Publication Type :
- Academic Journal
- Accession number :
- 33482364
- Full Text :
- https://doi.org/10.1016/j.aohep.2021.100309