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Effect of cultivation ages on anti-inflammatory activity of a new type of red ginseng.
Effect of cultivation ages on anti-inflammatory activity of a new type of red ginseng.
- Source :
-
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Apr; Vol. 136, pp. 111280. Date of Electronic Publication: 2021 Jan 20. - Publication Year :
- 2021
-
Abstract
- Ginseng has been widely applied in clinical practice, but the cultivation age cannot be ignored as it influences the quality of ginseng and its products. In this work, different cultivation ages of fresh ginseng (FG) from four to seven years were analysed by UPLC-Q-TOF-MS/MS. Principal component analysis and supervised orthogonal partial least squared discrimination analysis, which belong to the normal method of multivariate statistical analysis, were applied to discover the characteristic components of FG at different cultivation ages. The components of new type of red ginseng (NRG) derived from FG at different cultivation ages were compared by HPLC analysis. The pharmacological anti-inflammatory activity was evaluated by ELISA and qPCR. The result showed that the characteristic components of both 6- and 7-year-old ginseng were ginsenoside Rb1, mal-ginsenoside Rb1, ginsenoside Rc, mal-ginsenoside Rc, mal-ginsenoside Rb1 isomer, and mal-ginsenoside Rb2. Moreover, the characteristic components of both 4- and 5-year-old ginseng were ADP-glucose and 3-hydroxyhexanoyl CoA. In addition, 6-year-old NRG has higher rare ginsenosides than 4-year-old NRG, which possesses great anti-inflammatory activity in vitro. The results reveal the ginsenoside transformation law of NRG processing and suggest that the cultivation age of FG influences the content of ginsenosides in NRG. Therefore, 6-year-old ginseng is more suitable for red ginseng processing and clinical use.<br /> (Copyright © 2021 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
- Subjects :
- Animals
Anti-Inflammatory Agents isolation & purification
Cell Line
Chromatography, High Pressure Liquid
Ginsenosides isolation & purification
Inflammation Mediators metabolism
Interleukin-6 metabolism
Least-Squares Analysis
Mice
Microglia metabolism
Nitric Oxide metabolism
Panax metabolism
Plant Extracts isolation & purification
Principal Component Analysis
Tandem Mass Spectrometry
Time Factors
Tumor Necrosis Factor-alpha metabolism
Anti-Inflammatory Agents pharmacology
Ginsenosides pharmacology
Microglia drug effects
Panax growth & development
Plant Extracts pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1950-6007
- Volume :
- 136
- Database :
- MEDLINE
- Journal :
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- Publication Type :
- Academic Journal
- Accession number :
- 33485063
- Full Text :
- https://doi.org/10.1016/j.biopha.2021.111280