Increased resistance to fibrinolysis activation in patients with coronavirus disease 2019: a case series.

Authors :: Duque P
Chasco-Ganuza M
Burgos-Santamaria A
Terradillos E
Source :: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis [Blood Coagul Fibrinolysis] 2021 Jun 01; Vol. 32 (4), pp. 298-301.
Publication Year :: 2021
Abstract: We describe seven critically ill and seven noncritically ill patients with coronavirus disease 2019 infection. Two viscoelastic assays were performed with ClotPro technology, activated by extrinsic system test and recombinant tissue plasminogen activator challenge test. Coagulation profile presents a marked hypercoagulability with increased resistance to fibrinolysis, reflected by tissue plasminogen activator test. Our pathological observations show that the hypercoagulative status described in these patients is, at least partially, secondary to fibrinolysis shutdown.<br /> (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)

Language :: English
ISSN :: 1473-5733
Volume :: 32
Issue :: 4
Database :: MEDLINE
Journal :: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
Publication Type :: Academic Journal
Accession number :: 33491994
Full Text :: https://doi.org/10.1097/MBC.0000000000001017

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