Back to Search
Start Over
Efficacy of a multivalent vaccine against Fasciola hepatica infection in sheep.
- Source :
-
Veterinary research [Vet Res] 2021 Jan 28; Vol. 52 (1), pp. 13. Date of Electronic Publication: 2021 Jan 28. - Publication Year :
- 2021
-
Abstract
- In this work we report the protection found in a vaccination trial performed in sheep with two different vaccines composed each one by a cocktail of antigens (rCL1, rPrx, rHDM and rLAP) formulated in two different adjuvants (Montanide ISA 61 VG (G1) and Alhydrogel <superscript>®</superscript> (G2)). The parameters of protection tested were fluke burden, faecal egg count and evaluation of hepatic lesions. In vaccinated group 1 we found a significant decrease in fluke burden in comparison to both unimmunised and infected control group (37.2%; p = 0.002) and to vaccinated group 2 (Alhydrogel <superscript>®</superscript> ) (27.08%; p = 0.016). The lower fluke burden found in G1 was accompanied by a decrease in egg output of 28.71% in comparison with the infected control group. Additionally, gross hepatic lesions found in vaccine 1 group showed a significant decrease (p = 0.03) in comparison with unimmunised-infected group. The serological study showed the highest level for both IgG1 and IgG2 in animals from group 1. All these data support the hypothesis of protection found in vaccine 1 group.
- Subjects :
- Adjuvants, Immunologic pharmacology
Animals
Fascioliasis immunology
Fascioliasis prevention & control
Sheep
Sheep Diseases immunology
Sheep, Domestic
Fasciola hepatica immunology
Fascioliasis veterinary
Sheep Diseases prevention & control
Vaccination veterinary
Vaccines, Combined pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1297-9716
- Volume :
- 52
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Veterinary research
- Publication Type :
- Academic Journal
- Accession number :
- 33509286
- Full Text :
- https://doi.org/10.1186/s13567-021-00895-0