A case of bronchiolitis obliterans after living-donor renal transplantation.

We herein report the case of a 20 year-old-man who developed bronchiolitis obliterans after living-donor renal transplantation. The patient presented with dyspnea on exertion and wheezing two years after renal transplantation, and spirometry showed an obstructive pattern. Surgical lung biopsy revealed subepithelial fibrosis that constricted and obstructed the intrabronchiolar space. Based on these findings, the patient was diagnosed with bronchiolitis obliterans. He was prescribed bronchodilators and azithromycin, and he achieved stable respiratory function for two years. The differential diagnosis of respiratory symptoms after renal transplantation includes opportunistic infection and drug-induced lung injury; however, bronchiolitis obliterans should also be considered.
Competing Interests: Conflict of interest M Hayashi, S Hokari, N Aoki, Y Ohshima, T Koya, M Tasaki, and K Saito declare that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article. S Watanabe received a research funding from Boehringer Ingelheim, and T Kikuchi received research funding from Boehringer Ingelheim, Chugai Pharmaceutical, and Eli Lilly.
(Copyright © 2021 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.)