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Convalescent plasma-mediated resolution of COVID-19 in a patient with humoral immunodeficiency.
- Source :
-
Cell reports. Medicine [Cell Rep Med] 2020 Dec 05; Vol. 2 (1), pp. 100164. Date of Electronic Publication: 2020 Dec 05 (Print Publication: 2021). - Publication Year :
- 2020
-
Abstract
- Convalescent plasma (CP) is widely used to treat COVID-19, but without formal evidence of efficacy. Here, we report the beneficial effects of CP in a severely ill COVID-19 patient with prolonged pneumonia and advanced chronic lymphocytic leukemia (CLL), who was unable to generate an antiviral antibody response of her own. On day 33 after becoming symptomatic, the patient received CP containing high-titer (ID <subscript>50</subscript> > 5,000) neutralizing antibodies (NAbs), defervesced, and improved clinically within 48 h and was discharged on day 37. Hence, when present in sufficient quantities, NAbs to SARS-CoV-2 have clinical benefit even if administered relatively late in the disease course. However, analysis of additional CP units revealed widely varying NAb titers, with many recipients exhibiting endogenous NAb responses far exceeding those of the administered units. To obtain the full therapeutic benefits of CP immunotherapy, it will thus be important to determine the neutralizing activity in both CP units and transfusion candidates.<br />Competing Interests: R.S.D. and K.H. have submitted an intellectual property disclosure related to the ACE2/RBD assay.<br /> (© 2020 The Author(s).)
- Subjects :
- Aged
Antibodies, Neutralizing administration & dosage
COVID-19 complications
COVID-19 pathology
COVID-19 virology
Female
Humans
Immunization, Passive
Immunocompromised Host
Leukemia, Lymphocytic, Chronic, B-Cell complications
Leukemia, Lymphocytic, Chronic, B-Cell pathology
Lung diagnostic imaging
SARS-CoV-2 isolation & purification
Severity of Illness Index
Tomography, X-Ray Computed
COVID-19 Serotherapy
COVID-19 therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2666-3791
- Volume :
- 2
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cell reports. Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 33521696
- Full Text :
- https://doi.org/10.1016/j.xcrm.2020.100164