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Microbiota-derived short-chain fatty acids do not interfere with SARS-CoV-2 infection of human colonic samples.
- Source :
-
Gut microbes [Gut Microbes] 2021 Jan-Dec; Vol. 13 (1), pp. 1-9. - Publication Year :
- 2021
-
Abstract
- Microbiota-derived molecules called short-chain fatty acids (SCFAs) play a key role in the maintenance of the intestinal barrier and regulation of immune response during infectious conditions. Recent reports indicate that SARS-CoV-2 infection changes microbiota and SCFAs production. However, the relevance of this effect is unknown. In this study, we used human intestinal biopsies and intestinal epithelial cells to investigate the impact of SCFAs in the infection by SARS-CoV-2. SCFAs did not change the entry or replication of SARS-CoV-2 in intestinal cells. These metabolites had no effect on intestinal cells' permeability and presented only minor effects on the production of anti-viral and inflammatory mediators. Together our findings indicate that the changes in microbiota composition of patients with COVID-19 and, particularly, of SCFAs do not interfere with the SARS-CoV-2 infection in the intestine.
- Subjects :
- Adult
Aged
Caco-2 Cells
Colon virology
Epithelial Cells virology
Female
Humans
In Vitro Techniques
Male
Middle Aged
SARS-CoV-2 pathogenicity
SARS-CoV-2 physiology
Viral Load
Virus Internalization
Young Adult
COVID-19 virology
Fatty Acids, Volatile metabolism
Gastrointestinal Microbiome
Intestinal Mucosa virology
Subjects
Details
- Language :
- English
- ISSN :
- 1949-0984
- Volume :
- 13
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Gut microbes
- Publication Type :
- Academic Journal
- Accession number :
- 33550892
- Full Text :
- https://doi.org/10.1080/19490976.2021.1874740