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Development of neovascular glaucoma after intraocular surgery in Pierson syndrome.
- Source :
-
Ophthalmic genetics [Ophthalmic Genet] 2021 Jun; Vol. 42 (3), pp. 317-319. Date of Electronic Publication: 2021 Feb 08. - Publication Year :
- 2021
-
Abstract
- Purpose : To report a patient with Pierson syndrome who presented with neovascular glaucoma (NVG) after cataract surgery. Methods : Retrospective case report. Results : A 17-year old monocular female presented with sudden onset of pain and decreased vision in the right eye. On examination, she had intraocular pressure (IOP) of 50 mmHg, aggressive iris neovascularization (NVI) and 3-piece IOL. Fundus examination revealed pale disc with tessellated fundus and parapapillary atrophy. Vascular arcades were vertically stretched with avascular ischemic retina starting from the near periphery. Macula appeared thin and atrophic. An intravitreal injection of 0.05 mg/0.1 ml bevacizumab was given to the right eye followed by Ahmed glaucoma valve (AGV) implantation. Assessment of her brother revealed similar posterior segment changes. A subsequent urine analysis showed proteinuria and high albumin to creatinine ratio. Next-generation sequencing for LAMB2 gene revealed a homozygous c.4573 + 1 G > A variant confirming the diagnosis of Pierson syndrome. Conclusion : This case expands our knowledge on retinal ischemia in the setting of Pierson syndrome. Close monitoring after intraocular surgery is recommended to look for the development of NVG.
- Subjects :
- Adolescent
Angiogenesis Inhibitors therapeutic use
Bevacizumab therapeutic use
Combined Modality Therapy
Female
Glaucoma Drainage Implants
Glaucoma, Neovascular diagnosis
Glaucoma, Neovascular therapy
High-Throughput Nucleotide Sequencing
Humans
Intraocular Pressure
Lens Implantation, Intraocular adverse effects
Male
Myasthenic Syndromes, Congenital diagnosis
Nephrotic Syndrome diagnosis
Pupil Disorders diagnosis
Retrospective Studies
Siblings
Tonometry, Ocular
Young Adult
Glaucoma, Neovascular etiology
Laminin genetics
Myasthenic Syndromes, Congenital complications
Myasthenic Syndromes, Congenital genetics
Nephrotic Syndrome complications
Nephrotic Syndrome genetics
Phacoemulsification adverse effects
Pupil Disorders complications
Pupil Disorders genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1744-5094
- Volume :
- 42
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Ophthalmic genetics
- Publication Type :
- Academic Journal
- Accession number :
- 33554690
- Full Text :
- https://doi.org/10.1080/13816810.2021.1881982