Characterization of an antioxidant pectic polysaccharide from Platycodon grandiflorus.

Authors :: Zou YF
Chen M
Fu YP
Zhu ZK
Zhang YY
Paulsen BS
Rise F
Chen YL
Yang YZ
Jia RY
Li LX
Song X
Tang HQ
Feng B
Lv C
Ye G
Wu DT
Yin ZQ
Huang C
Source :: International journal of biological macromolecules [Int J Biol Macromol] 2021 Apr 01; Vol. 175, pp. 473-480. Date of Electronic Publication: 2021 Feb 08.
Publication Year :: 2021
Abstract: Platycodonis Radix is widely used as homology of medicine and food in China; polysaccharides are thought to be one of its functional constituents. In this study, a pectic polysaccharide, PGP-I-I, was obtained from the root of the traditional medicine plant Platycodon grandiflorus through ion exchange chromatography and gel filtration. This was characterized being mainly composed of 1,5-α-L-arabinan and both arabinogalactan type I (AG-I) and II chains linked to rhamnogalacturonan I (RG-I) backbone linked to longer galacturonan chains. In vitro bioactivity study showed that PGP-I-I could restore the intestinal cellular antioxidant defense under the condition of hydrogen peroxide (H <subscript>2</subscript> O <subscript>2</subscript> ) treatment through promoting the expressions of cellular antioxidant genes and protect against oxidative damages.<br /> (Copyright © 2021. Published by Elsevier B.V.)

Subjects :: Animals
Antioxidants chemistry
Antioxidants isolation & purification
Cell Line
Chromatography, Gel
Chromatography, Ion Exchange
Dietary Carbohydrates
Galactans chemistry
Hydrogen Peroxide
Plant Extracts chemistry
Plant Roots chemistry
Polysaccharides chemistry
Swine
Pectins chemistry
Platycodon chemistry

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