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Dysmorphic neurons as cellular source for phase-amplitude coupling in Focal Cortical Dysplasia Type II.
- Source :
-
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology [Clin Neurophysiol] 2021 Mar; Vol. 132 (3), pp. 782-792. Date of Electronic Publication: 2021 Jan 20. - Publication Year :
- 2021
-
Abstract
- Objective: Reliable localization of the epileptogenic zone is necessary for successful epilepsy surgery. Neurophysiological biomarkers include ictal onsets and interictal spikes. Furthermore, the epileptic network shows oscillations with potential localization value and pathomechanistic implications. The cellular origin of such markers in invasive EEG in vivo remains to be clarified.<br />Methods: In the presented pilot study, surgical brain samples and invasive EEG recordings of seven patients with surgically treated Focal Cortical Dysplasia (FCD) type II were coregistered using a novel protocol. Dysmorphic neurons and balloon cells were immunohistochemically quantified. Evaluated markers included seizure onset, spikes, and oscillatory activity in delta, theta, gamma and ripple frequency bands, as well as sample entropy and phase-amplitude coupling between delta, theta, alpha and beta phase and gamma amplitude.<br />Results: Correlations between histopathology and neurophysiology provided evidence for a contribution of dysmorphic neurons to interictal spikes, fast gamma activity and ripples. Furthermore, seizure onset and phase-amplitude coupling in areas with dysmorphic neurons suggests preserved connectivity is related to seizure initiation. Balloon cells showed no association.<br />Conclusions: Phase-amplitude coupling, spikes, fast gamma and ripples are related to the density of dysmorphic neurons and localize the seizure onset zone.<br />Significance: The results of our pilot study provide a new powerful tool to address the cellular source of abnormal neurophysiology signals to leverage current and novel biomarkers for the localization of epileptic activity in the human brain.<br />Competing Interests: Disclosure of Conflicts of Interest None of the authors has any conflict of interest to disclose.<br /> (Copyright © 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Adolescent
Adult
Child
Child, Preschool
Epilepsy diagnostic imaging
Female
Humans
Male
Malformations of Cortical Development, Group I diagnostic imaging
Neurons pathology
Pilot Projects
Proof of Concept Study
Retrospective Studies
Electrodes, Implanted
Electroencephalography methods
Epilepsy physiopathology
Epilepsy surgery
Malformations of Cortical Development, Group I physiopathology
Malformations of Cortical Development, Group I surgery
Neurons physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-8952
- Volume :
- 132
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
- Publication Type :
- Academic Journal
- Accession number :
- 33571886
- Full Text :
- https://doi.org/10.1016/j.clinph.2021.01.004