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Multiple Applications of a Novel Biarsenical Imaging Probe in Fluorescence and PET Imaging of Melanoma.
- Source :
-
Bioconjugate chemistry [Bioconjug Chem] 2021 Mar 17; Vol. 32 (3), pp. 497-501. Date of Electronic Publication: 2021 Feb 12. - Publication Year :
- 2021
-
Abstract
- A new fluorescent biarsenical peptide labeling probe was synthesized and labeled with the radioactive isotopes <superscript>11</superscript> C and <superscript>18</superscript> F. The utility of this probe was demonstrated by installing each of these isotopes into a melanocortin 1 receptor (MC1R) binding peptide, which targets melanoma tumors. Its applicability was further showcased by subsequent in vitro imaging in cells as well as in vivo imaging in melanoma xenograft mice by fluorescence and positron emission tomography.
Details
- Language :
- English
- ISSN :
- 1520-4812
- Volume :
- 32
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Bioconjugate chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 33576604
- Full Text :
- https://doi.org/10.1021/acs.bioconjchem.0c00671