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Fast Dissolution Electrospun Medicated Nanofibers for Effective Delivery of Poorly Water-Soluble Drug.
- Source :
-
Current drug delivery [Curr Drug Deliv] 2022; Vol. 19 (4), pp. 422-435. - Publication Year :
- 2022
-
Abstract
- Background: Electrospinning is developing rapidly from an earlier laboratory method into an industrial process. The clinical applications of this technique are approached in various ways through electrospun medicated nanofibers. Fast-dissolving oral drug delivery systems (DDSs) have promising commercial applications in the near future.<br />Methods: Related papers have been investigated in this study, including the latest research results on electrospun nanofiber-based fast-dissolution DDSs.<br />Results: The following related topics are concluded: 1) development of electrospinning, ranging from one-fluid blending to multi-fluid process and potential applications in the formation of medicated nanofibers involving poorly water-soluble drugs; 2) selection of appropriate polymer matrices and drug carriers for filament formation; 3) types of poorly water-soluble drugs ideal for fast oral delivery; 4) methods for evaluating fast-dissolving nanofibers; 5) mechanisms that promote the fast dissolution of poorly water-soluble drugs by electrospun nanofibers; 6) and important issues related to further development of electrospun medicated nanofibers as oral fast-dissolving drug delivery systems.<br />Conclusion and Perspective: Given their unique properties, electrospun-medicated nanofibers can be used as oral fast-dissolving DDSs of poorly water-soluble drugs. However, significant issues, such as scalable productions and solid dosage form conversions, need to be investigated.<br /> (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
- Subjects :
- Drug Carriers
Drug Delivery Systems
Solubility
Water
Nanofibers
Subjects
Details
- Language :
- English
- ISSN :
- 1875-5704
- Volume :
- 19
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Current drug delivery
- Publication Type :
- Academic Journal
- Accession number :
- 33588728
- Full Text :
- https://doi.org/10.2174/1567201818666210215110359