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Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets.
- Source :
-
Science (New York, N.Y.) [Science] 2021 Mar 26; Vol. 371 (6536), pp. 1379-1382. Date of Electronic Publication: 2021 Feb 17. - Publication Year :
- 2021
-
Abstract
- Containment of the COVID-19 pandemic requires reducing viral transmission. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is initiated by membrane fusion between the viral and host cell membranes, which is mediated by the viral spike protein. We have designed lipopeptide fusion inhibitors that block this critical first step of infection and, on the basis of in vitro efficacy and in vivo biodistribution, selected a dimeric form for evaluation in an animal model. Daily intranasal administration to ferrets completely prevented SARS-CoV-2 direct-contact transmission during 24-hour cohousing with infected animals, under stringent conditions that resulted in infection of 100% of untreated animals. These lipopeptides are highly stable and thus may readily translate into safe and effective intranasal prophylaxis to reduce transmission of SARS-CoV-2.<br /> (Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)
- Subjects :
- Administration, Intranasal
Animals
COVID-19 prevention & control
COVID-19 virology
Chlorocebus aethiops
Disease Models, Animal
Drug Design
Ferrets
Lipopeptides chemistry
Lipopeptides pharmacokinetics
Lipopeptides pharmacology
Mice
Pre-Exposure Prophylaxis
SARS-CoV-2 isolation & purification
SARS-CoV-2 physiology
Spike Glycoprotein, Coronavirus metabolism
Tissue Distribution
Vero Cells
Viral Fusion Protein Inhibitors chemistry
Viral Fusion Protein Inhibitors pharmacokinetics
Viral Fusion Protein Inhibitors pharmacology
COVID-19 transmission
Lipopeptides administration & dosage
Membrane Fusion drug effects
SARS-CoV-2 drug effects
Viral Fusion Protein Inhibitors administration & dosage
Virus Internalization drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9203
- Volume :
- 371
- Issue :
- 6536
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 33597220
- Full Text :
- https://doi.org/10.1126/science.abf4896