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Consecutive β,β'-Selective C(sp 3 )-H Silylation of Tertiary Amines with Dihydrosilanes Catalyzed by B(C 6 F 5 ) 3 .
- Source :
-
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2021 Apr 06; Vol. 60 (15), pp. 8542-8546. Date of Electronic Publication: 2021 Mar 03. - Publication Year :
- 2021
-
Abstract
- Tris(pentafluorophenyl)borane has been found to catalyze the two-fold C(sp <superscript>3</superscript> )-H silylation of various trialkylamine derivatives with dihydrosilanes, furnishing the corresponding 4-silapiperidines in decent yields. The multi-step reaction cascade involves amine-to-enamine dehydrogenation at two alkyl residues and two electrophilic silylation reactions of those enamines, one inter- and one intramolecular.<br /> (© 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.)
Details
- Language :
- English
- ISSN :
- 1521-3773
- Volume :
- 60
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Angewandte Chemie (International ed. in English)
- Publication Type :
- Academic Journal
- Accession number :
- 33604987
- Full Text :
- https://doi.org/10.1002/anie.202016664