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COR-101, ein menschlicher Antikörper gegen COVID-19.
- Source :
-
Biospektrum : Zeitschrift der Gesellschaft fur Biologishe Chemie (GBCH) und der Vereinigung fur Allgemeine und Angewandte Mikrobiologie (VAAM) [Biospektrum (Heidelb)] 2021; Vol. 27 (1), pp. 46-48. Date of Electronic Publication: 2021 Feb 12. - Publication Year :
- 2021
-
Abstract
- COR-101 is a fully human, Fc silenced IgG that was discovered by antibody phage display. It reduced the SARS-CoV-2 virus load in the lung by more than 99 percent in Hamster models and led to much faster recovery. Its mode of action has been elucidated by solving the atomic structure of its interaction with SARS-CoV-2. The antibody competes with ACE2 binding by blocking a large area of the SARS-CoV-2 spike protein.<br /> (© Die Autoren 2021.)
Details
- Language :
- German
- ISSN :
- 0947-0867
- Volume :
- 27
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Biospektrum : Zeitschrift der Gesellschaft fur Biologishe Chemie (GBCH) und der Vereinigung fur Allgemeine und Angewandte Mikrobiologie (VAAM)
- Publication Type :
- Academic Journal
- Accession number :
- 33612989
- Full Text :
- https://doi.org/10.1007/s12268-021-1512-x