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Brain network analysis reveals that amyloidopathy affects comorbid cognitive dysfunction in older adults with depression.
- Source :
-
Scientific reports [Sci Rep] 2021 Feb 22; Vol. 11 (1), pp. 4299. Date of Electronic Publication: 2021 Feb 22. - Publication Year :
- 2021
-
Abstract
- Late-life depression (LLD) may increase the risk of Alzheimer's dementia (AD). While amyloidopathy accelerates AD progression, its role in such patients has not yet been elucidated. We hypothesized that cerebral amyloidopathy distinctly affects the alteration of brain network topology and may be associated with distinct cognitive symptoms. We recruited 26 and 27 depressed mild cognitive impairment (MCI) patients with (LLD-MCI-A(+)) and without amyloid accumulation (LLD-MCI-A(-)), respectively, and 21 normal controls. We extracted structural brain networks using their diffusion-weighted images. We aimed to compare the distinct network deterioration in LLD-MCI with and without amyloid accumulation and the relationship with their distinct cognitive decline. Thus, we performed a group comparison of the network topological measures and investigated any correlations with neurocognitive testing scores. Topological features of brain networks were different according to the presence of amyloid accumulation. Disrupted network connectivity was highly associated with impaired recall and recognition in LLD-MCI-A(+) patients. Inattention and dysexecutive function were more influenced by the altered networks involved in fronto-limbic circuitry dysfunction in LLD-MCI-A(-) patients. Our results show that alterations in brain network topology may reflect different cognitive dysfunction depending on amyloid accumulation in depressed older adults with MCI.
- Subjects :
- Age Factors
Aged
Aged, 80 and over
Amyloidosis diagnosis
Cognitive Dysfunction diagnosis
Connectome methods
Depression diagnosis
Female
Humans
Magnetic Resonance Imaging
Male
Amyloidosis complications
Brain pathology
Brain physiopathology
Cognitive Dysfunction etiology
Cognitive Dysfunction psychology
Depression etiology
Depression psychology
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 11
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 33619307
- Full Text :
- https://doi.org/10.1038/s41598-021-83739-3