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The Prognostic Value of a Validated and Automated Intravascular Ultrasound-Derived Calcium Score.

Authors :
Neleman T
Liu S
Tovar Forero MN
Hartman EMJ
Ligthart JMR
Witberg KT
Cummins P
Zijlstra F
Van Mieghem NM
Boersma E
van Soest G
Daemen J
Source :
Journal of cardiovascular translational research [J Cardiovasc Transl Res] 2021 Oct; Vol. 14 (5), pp. 992-1000. Date of Electronic Publication: 2021 Feb 23.
Publication Year :
2021

Abstract

Background: Coronary calcification has been linked to cardiovascular events. We developed and validated an algorithm to automatically quantify coronary calcifications on intravascular ultrasound (IVUS). We aimed to assess the prognostic value of an IVUS-calcium score (ICS) on patient-oriented composite endpoint (POCE).<br />Methods: We included patients that underwent coronary angiography plus pre-procedural IVUS imaging. The ICS was calculated per patient. The primary endpoint was a composite of all-cause mortality, stroke, myocardial infarction, and revascularization (POCE).<br />Results: In a cohort of 408 patients, median ICS was 85. Both an ICS ≥ 85 and a 100 unit increase in ICS increased the risk of POCE at 6-year follow-up (adjusted hazard ratio (aHR) 1.51, 95%CI 1.05-2.17, p value = 0.026, and aHR 1.21, 95%CI 1.04-1.41, p value = 0.014, respectively).<br />Conclusions: The ICS, calculated by a validated automated algorithm derived from routine IVUS pullbacks, was strongly associated with the long-term risk of POCE.<br /> (© 2021. The Author(s).)

Details

Language :
English
ISSN :
1937-5395
Volume :
14
Issue :
5
Database :
MEDLINE
Journal :
Journal of cardiovascular translational research
Publication Type :
Academic Journal
Accession number :
33624259
Full Text :
https://doi.org/10.1007/s12265-021-10103-1