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Measurement of cellular-interstitial water exchange time in tumors based on diffusion-time-dependent diffusional kurtosis imaging.
- Source :
-
NMR in biomedicine [NMR Biomed] 2021 Jun; Vol. 34 (6), pp. e4496. Date of Electronic Publication: 2021 Feb 25. - Publication Year :
- 2021
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Abstract
- Purpose: To assess the feasibility of using diffusion-time-dependent diffusional kurtosis imaging (tDKI) to measure cellular-interstitial water exchange time (τ <subscript>ex</subscript> ) in tumors, both in animals and in humans.<br />Methods: Preclinical tDKI studies at 7 T were performed with the GL261 glioma model and the 4T1 mammary tumor model injected into the mouse brain. Clinical studies were performed at 3 T with women who had biopsy-proven invasive ductal carcinoma. tDKI measurement was conducted using a diffusion-weighted STEAM pulse sequence with multiple diffusion times (20-800 ms) at a fixed echo time, while keeping the b-values the same (0-3000 s/mm <superscript>2</superscript> ) by adjusting the diffusion gradient strength. The tDKI data at each diffusion time t were used for a weighted linear least-squares fit method to estimate the diffusion-time-dependent diffusivity, D(t), and diffusional kurtosis, K(t).<br />Results: Both preclinical and clinical studies showed that, when diffusion time t ≥ 200 ms, D(t) did not have a noticeable change while K(t) decreased monotonically with increasing diffusion time in tumors and t ≥ 100 ms for the cortical ribbon of the mouse brain. The estimated τ <subscript>ex</subscript> averaged median and interquartile range (IQR) of GL261 and 4T1 tumors were 93 (IQR = 89) ms and 68 (78) ms, respectively. For the cortical ribbon, the estimated τ <subscript>ex</subscript> averaged median and IQR were 41 (34) ms for C57BL/6 and 30 (17) ms for BALB/c. For invasive ductal carcinoma, the estimated τ <subscript>ex</subscript> median and IQR of the two breast cancers were 70 (94) and 106 (92) ms.<br />Conclusion: The results of this proof-of-concept study substantiate the feasibility of using tDKI to measure cellular-interstitial water exchange time without using an exogenous contrast agent.<br /> (© 2021 John Wiley & Sons, Ltd.)
- Subjects :
- Animals
Brain Neoplasms diagnostic imaging
Brain Neoplasms pathology
Breast Neoplasms
Disease Models, Animal
Female
Glioma diagnostic imaging
Glioma pathology
Humans
Mammary Neoplasms, Animal diagnostic imaging
Mammary Neoplasms, Animal pathology
Mice, Inbred BALB C
Mice, Inbred C57BL
Neoplasms pathology
Mice
Diffusion Tensor Imaging
Neoplasms diagnostic imaging
Water chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1099-1492
- Volume :
- 34
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- NMR in biomedicine
- Publication Type :
- Academic Journal
- Accession number :
- 33634508
- Full Text :
- https://doi.org/10.1002/nbm.4496